Abstract: Rural and remote communities’ health and wellbeing needs are often more complex than those of urban communities (AIHW, 2022). Inadequate healthcare resources and infrastructure compounds poorer health outcomes and poorer access to, and use of, healthcare services (AIHW, 2022; Edelman, et al., 2020). As a result, rural and remote Registered Nurses (RNs) practice with greater autonomy. This autonomy still requires RNs to closely engage with their colleagues and communities, to deliver effective healthcare in diverse cultural and geographical contexts. This unique context of practice offers highly rewarding professional and leadership opportunities for RNs’ career development. The intent of the National Rural and Remote Nursing Generalist Framework 2023–2027 (the Framework) is to describe this unique context of practice and core capabilities for rural and remote RN practice. It is underpinned by the Nursing and Midwifery Board of Australia’s (NMBA) Registered Nurse Standards for Practice (2016).