The association between diabetes and human T-Cell Leukaemia Virus Type-1 (HTLV-1) with Strongyloides stercoralis: Results of a community-based, cross-sectional survey in central Australia

The association between diabetes and human T-Cell Leukaemia Virus Type-1 (HTLV-1) with Strongyloides stercoralis: Results of a community-based, cross-sectional survey in central Australia Journal Article

International Journal of Environmental Research and Public Health

  • Author(s): Talukder, Mohammad R., Pham, Hai, Woodman, Richard, Wilson, Kim, Taylor, Kerry, Kaldor, John, Einsiedel, Lloyd
  • Published: 2022
  • Volume: 19
  • ISBN: 1660-4601

Abstract: In central Australia, an area that is endemic for the human T-cell leukaemia virus type-1 (HTLV-1), the prevalence of Strongyloides stercoralis and its association with other health conditions are unknown. A cross-sectional community-based survey was conducted in seven remote Aboriginal communities in central Australia, from 2014 to 2018. All residents aged ≥10 years were invited to complete a health survey and to provide blood for Strongyloides serology, HTLV-1 serology and HTLV-1 proviral load (PVL). Risk factors for Strongyloides seropositivity and associations with specific health conditions including diabetes and HTLV-1 were determined using logistic regression. Overall Strongyloides seroprevalence was 27% (156/576) (children, 22% (9/40); adults (≥15 years), 27% (147/536), varied widely between communities (5–42%) and was not associated with an increased risk of gastrointestinal, respiratory or dermatological symptoms. Increasing age, lower HTLV-1 PVL (<1000 copies per 10^5 peripheral blood leucocytes) compared to the HTLV-1 uninfected group and community of residence were significant risk factors for Strongyloides seropositivity in an adjusted model. A modest reduction in the odds of diabetes among Strongyloides seropositive participants was found (aOR 0.58, 95% CI 0.35, 1.00; p = 0.049); however, this was lost when body mass index was included in the adjusted model (aOR 0.48, 95% CI 0.48, 1.47; p = 0.542). Strongyloides seropositivity had no relationship with anaemia. Exploring social and environmental practices in communities with low Strongyloides seroprevalence may provide useful lessons for similar settings.

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Suggested Citation
Talukder, Mohammad R., Pham, Hai, Woodman, Richard, Wilson, Kim, Taylor, Kerry, Kaldor, John, Einsiedel, Lloyd, 2022, The association between diabetes and human T-Cell Leukaemia Virus Type-1 (HTLV-1) with Strongyloides stercoralis: Results of a community-based, cross-sectional survey in central Australia, Volume:19, Journal Article, viewed 04 July 2022, https://www.nintione.com.au/?p=29105.

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