Social and economic factors, maternal behaviours in pregnancy and neonatal adiposity in the PANDORA cohort

Social and economic factors, maternal behaviours in pregnancy and neonatal adiposity in the PANDORA cohort Journal Article

Diabetes Research and Clinical Practice

  • Author(s): Krista Longmore, Danielle, Laurel Mary Barr, Elizabeth, Barzi, Federica, Lee, I. Lynn, Kirkwood, Marie, Connors, Christine, Boyle, Jacqueline, O'Dea, Kerin, Zimmet, Paul, Oats, Jeremy, Catalano, Patrick, David Mcintyre, H., Brown, Alex D. H., Shaw, Jonathan E., Maple-Brown, Louise J.
  • Published: 2020
  • ISBN: 0168-8227

Abstract: Background Australian Indigenous women experience high rates of social disadvantage and type 2 diabetes (T2D) in pregnancy, but it is not known how social factors and maternal behaviours impact neonatal adiposity in offspring of women with hyperglycaemia in pregnancy. Methods Participants were Indigenous (n=404) and Europid (n=240) women with gestational diabetes mellitus (GDM) or T2D in pregnancy and their offspring in the Pregnancy and Neonatal Diabetes Outcomes in Remote Australia (PANDORA) study. Social, economic factors, and maternal behaviours were measured in pregnancy and six neonatal anthropometric outcomes were examined after birth. Results On univariate analysis, maternal education <12 years (p=0.03), unemployment (p=0.001), welfare income vs no welfare income (p=0.001), lower area based socio-economic score (p<0.001), and fast food intake >2 times/week (p=0.002) were associated with increased sum of skinfolds (SSF) in offspring. Smoking was significantly associated with a reduction in anthropometric measures, except SSF. In multivariable models adjusted for ethnicity, BMI and hyperglycaemia, social and economic factors were no longer significant predictors of neonatal outcomes. Smoking was independently associated with a reduction in length, head circumference and fat free mass. Frequent fast food intake remained independently associated with SSF (β-coefficient 1.08mm, p=0.02). Conclusion In women with hyperglycaemia in pregnancy, social factors were associated with neonatal adiposity, particularly skinfold measures. Promoting smoking cessation and limited intake of energy-dense, nutrient-poor foods in pregnancy are important to improve neonatal adiposity and lean mass outcomes. Addressing inequities in social and economic factors are likely to be important, particularly for Indigenous women or women experiencing social disadvantage.

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Suggested Citation
Krista Longmore, Danielle, Laurel Mary Barr, Elizabeth, Barzi, Federica, Lee, I. Lynn, Kirkwood, Marie, Connors, Christine, Boyle, Jacqueline, O'Dea, Kerin, Zimmet, Paul, Oats, Jeremy, Catalano, Patrick, David Mcintyre, H., Brown, Alex D. H., Shaw, Jonathan E., Maple-Brown, Louise J., 2020, Social and economic factors, maternal behaviours in pregnancy and neonatal adiposity in the PANDORA cohort, Journal Article, viewed 06 July 2020, https://www.nintione.com.au/?p=16469.

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