Abstract: The prevalence of human T-cell lymphotropic virus type 1 (HTLV-1) and hepatitis B virus (HBV) coinfection is high in certain Indigenous Australian populations, but its impact on HTLV-1 has not been described. We compared 2 groups of Indigenous adults infected with HTLV-1, either alone or coinfected with HBV. The 2 groups had a similar HTLV-1 proviral load, but there was a significant increase in clonal expansion of HTLV-1–infected lymphocytes in coinfected asymptomatic individuals. The degree of clonal expansion was correlated with the titer of HBV surface antigen. We conclude that HTLV-1/HBV coinfection may predispose to HTLV-1–associated malignant disease.
Turpin, Jocelyn, Yurick, David, Khoury, Georges, Pham, Hai, Locarnini, Stephen, Melamed, Anat, Witkover, Aviva, Wilson, Kim, Purcell, Damian, Bangham, Charles R. M., Einsiedel, Lloyd, 2018, Impact of hepatitis B virus coinfection on human T-lymphotropic virus Type 1 clonality in an Indigenous population of central Australia, Journal Article, viewed 16 August 2022, https://www.nintione.com.au/?p=13863.