Abstract: •Macro-ecological modelling indicates that the impacts of climate change will vary across biological groups and, for a number of these groups, will be greater in some regions of the Rangelands Cluster. •The three groups that will be most impacted by climate change are plants, snails and reptiles; impacts on mammals will be moderate, whereas impacts on birds and frogs will be low. •Future climate refugia are modelled to occur in the MacDonnell and Central Ranges (NT Arid Lands sub-region, WA Rangelands and Alinytjara Wilurara regions), the Channel Country (Desert Channels and SA Arid Lands regions), Mount Isa Inlier (Desert Channels region), the Gibson Desert, the Pilbara (both WA Rangelands), the Nullarbor (WA Rangelands and Alinytjara Wilurara regions) and parts of inland Queensland and NSW (Western LLS and South West Queensland regions)