Abstract: This resource sheet discusses the harms resulting from tobacco use in Aboriginal and Torres Strait Islander communities, and evidence-based approaches to reducing this harm. To be effective, strategies to reduce tobacco use need to acknowledge the historical context for its use, as well as the many socioeconomic influences. Tobacco interventions that have been developed by and/or for Aboriginal and Torres Strait Islander communities, and interventions that may be suitable for translation for use in such communities are considered. To ensure that program delivery meets the highest standard it should involve the community in design, delivery and evaluation.