Absence of an important vaccine and diagnostic target in carriage- and disease-related nontypeable Haemophilus influenzae

Absence of an important vaccine and diagnostic target in carriage- and disease-related nontypeable Haemophilus influenzae Journal Article

Clinical and Vaccine Immunology

  • Author(s): Smith-Vaughan Heidi, C., Chang Anne, B., Sarovich Derek, S., Marsh Robyn, L., Grimwood, Keith, Leach Amanda, J., Morris Peter, S., Price Erin, P., Pasetti, M. F.
  • Published: 2014
  • Publisher: American Society for Microbiology
  • Volume: 21

Abstract: Nontypeable Haemophilus influenzae (NTHi)-associated disease is a major health problem globally. Whole-genome sequence analysis identified the absence of hpd genes encoding Haemophilus protein D in 3 of 16 phylogenetically distinct NTHi isolates. This novel finding is of potential clinical significance, as protein D and hpd represent important NTHi vaccine antigen and diagnostic targets, respectively.

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Suggested Citation
Smith-Vaughan Heidi, C., Chang Anne, B., Sarovich Derek, S., Marsh Robyn, L., Grimwood, Keith, Leach Amanda, J., Morris Peter, S., Price Erin, P., Pasetti, M. F., 2014, Absence of an important vaccine and diagnostic target in carriage- and disease-related nontypeable Haemophilus influenzae, Volume:21, Journal Article, viewed 13 June 2024, https://www.nintione.com.au/?p=30576.

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