Feasibility of once weekly exenatide-LAR and enhanced diabetes care in Indigenous Australians with type 2 diabetes. (Long-acting-Once-Weekly-Exenatide laR-SUGAR, “Lower SUGAR” study)

Internal Medicine Journal

Author(s): Ekinci, Elif I., Pyrlis, Felicity, Hachem, Mariam, Maple-Brown, Louise, Brown, Alex, Maguire, Graeme, Churilov, Leonid, Cohen, Neale
Published: 2021
Publisher: John Wiley & Sons, Ltd
Volume: n/a
ISBN: 1444-0903

Abstract: Aims To assess the feasibility and metabolic effects of once weekly supervised injection of exenatide-LAR in addition to standard care in Indigenous Australians with type 2 diabetes. Methods Two communities in Central Australia with longstanding specialist clinical outreach services were allocated by random coin toss to receive once-weekly exenatide-LAR injection with weekly nurse review and adjustment of medication for 20?weeks (community with exenatide-LAR) or to weekly nurse review in addition to standard care over 20?weeks (community without exenatide-LAR). The primary outcome was the feasibility of the intensive diabetes management model of care with and without weekly supervised exenatide-LAR. Secondary outcomes included change in HbA1c. Results 13 participants from community with exenatide-LAR and 9 participants from the community without exenatide-LAR were analysed. 85% of individuals in the community with exenatide-LAR and 67% in the community without exenatide-LAR attended more than half of clinic visits. Median difference in the change in HbA1c from baseline to final visit, adjusted for baseline HbA1c, between the community with exenatide-LAR and the community without exenatide-LAR was -3.1%, 95% CI (-5.80%, -0.38%; p = 0.03). Conclusions Weekly exenatide-LAR combined with weekly nurse review demonstrated greater improvements in HbA1c, highlighting its potential for use in remote communities.

Urls: https://doi.org/10.1111/imj.15428
Keywords: diabetes, Indigenous Australians, exenatide- LAR, hyperglycaemia, remote, type 2

Share this page

Search again