Efficacy of albendazole against Giardia and hookworm in a remote Aboriginal community in the north of Western Australia
Efficacy of albendazole against Giardia and hookworm in a remote Aboriginal community in the north of Western Australia
Acta Tropica
- Author(s): Reynoldson, J. A., Behnke, J. M., Gracey, M., Horton, R. J., Spargo, R., Hopkins, R. M., Constantine, C. C., Gilbert, F., Stead, C., Hobbs, R. P., Thompson, R. C. A.
- Published: 1998
- Volume: 71
- ISBN: 0001-706X
Abstract: The parasitological, clinical efficacy and tolerability of albendazole in the treatment for both giardiasis and hookworm infection in a remote Aboriginal population was investigated. Albendazole at a dose rate of 400 mg daily for 5 days was highly effective in reducing hookworm egg numbers and both Giardia antigen and cysts. The 36.6% prevalence of Giardia prior to treatment fell to 12% between days 6 and 9, 15% for days 10–17 and rose to 28% between days 18 and 30. Tolerability and clinical efficacy were excellent. The effect of albendazole on hookworm was longer lasting than that on Giardia, reducing percent infection from over 76–2% on days 6–9 and zero by day 18–30 despite conditions highly conducive to rapid re-infection. We conclude that albendazole is highly efficacious against both parasites when used as described but that long term community benefit may require additional education programmes to avoid re-infection with Giardia although treatment strategies would seem appropriate for hookworm.
- Urls: https://www.sciencedirect.com/science/article/pii/S0001706X98000485
- Keywords: Albendazole, Hookworm