Absence of an important vaccine and diagnostic target in carriage- and disease-related nontypeable Haemophilus influenzae
Absence of an important vaccine and diagnostic target in carriage- and disease-related nontypeable Haemophilus influenzae
Clinical and Vaccine Immunology
- Author(s): Smith-Vaughan Heidi, C., Chang Anne, B., Sarovich Derek, S., Marsh Robyn, L., Grimwood, Keith, Leach Amanda, J., Morris Peter, S., Price Erin, P., Pasetti, M. F.
- Published: 2014
- Publisher: American Society for Microbiology
- Volume: 21
Abstract: Nontypeable Haemophilus influenzae (NTHi)-associated disease is a major health problem globally. Whole-genome sequence analysis identified the absence of hpd genes encoding Haemophilus protein D in 3 of 16 phylogenetically distinct NTHi isolates. This novel finding is of potential clinical significance, as protein D and hpd represent important NTHi vaccine antigen and diagnostic targets, respectively.